Acylphloroglucinol, Biyouyanagiol, Biyouyanagin B, and Related Spiro-lactones from Hypericum chinense
Journal of Natural Products2009Vol. 72(8), pp. 1447–1452
Citations Over TimeTop 10% of 2009 papers
Naonobu Tanaka, Yoshiki Kashiwada, Sang Yong Kim, Waka Hashida, Michiko Sekiya, Yasumasa Ikeshiro, Yoshihisa Takaishi
Abstract
Biyouyanagiol (1), an acylphloroglucinol-related compound having a unique cyclopenta-1,3-dione moiety, was isolated from a Japanese traditional medicinal plant, Hypericum chinense, together with three new spiro-lactone-related derivatives, biyouyanagin B (2), 5,6-dihydrohyperolactone D (3), and 4-hydroxyhyperolactone D (4). Their structures were established on the basis of spectroscopic evidence. In a cytotoxicity assay against human cancer cell lines including multidrug-resistant (MDR) cancer cell lines, several compounds demonstrated enhanced cytotoxicity against MDR KB cells in the presence of colchicine.
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