Isoprenylated Chromone Derivatives from the Plant Endophytic Fungus Pestalotiopsis fici
Journal of Natural Products2009Vol. 72(8), pp. 1482–1486
Citations Over TimeTop 10% of 2009 papers
Abstract
Pestaloficiols F-L (1-7), new isoprenylated chromone derivatives including one heterodimer (7), have been isolated from a scale-up fermentation extract of the plant endophytic fungus Pestalotiopsis fici. The structures of these compounds were elucidated primarily by NMR and MS methods. The absolute configurations of 1 and 4 were assigned using the modified Mosher method. Compounds 1-3, 5, and 6 displayed inhibitory effects on HIV-1 replication in C8166 cells, whereas 4-7 showed cytotoxic activity against the human tumor cell lines HeLa and MCF7.
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