Quassidines A−D, Bis-β-carboline Alkaloids from the Stems of Picrasma quassioides
Journal of Natural Products2010Vol. 73(2), pp. 167–171
Citations Over TimeTop 21% of 2010 papers
Wei‐Hua Jiao, Hao Gao, Chenyang Li, Feng Zhao, Ren‐Wang Jiang, Ying Wang, Guang‐Xiong Zhou, Xin‐Sheng Yao
Abstract
Four new bis-beta-carboline alkaloids, quassidines A-D (1-4), together with a known alkaloid, picrasidine C (5), were isolated from the stems of Picrasma quassioides. Quassidine A (1) is the first reported bis-beta-carboline alkaloid possessing a novel cyclobutane moiety. The structures of the new compounds were determined on the basis of their 1D and 2D NMR and X-ray diffraction data. A possible biogenetic pathway for these alkaloids was proposed, and all compounds were evaluated for anti-inflammatory activity. Only quassidine A (1) showed weak activity.
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