A β-Carboline Alkaloid from the Papua New Guinea Marine Sponge Hyrtios reticulatus
Journal of Natural Products2009Vol. 73(2), pp. 255–257
Citations Over TimeTop 10% of 2009 papers
Wayne D. Inman, Walter M. Bray, N.C. Gassner, R. Scott Lokey, Karen Tenney, Yongchun Shen, Karen TenDyke, Ted Suh, Phillip Crews
Abstract
A new 1-imidazoyl-3-carboxy-6-hydroxy-beta-carboline alkaloid, named hyrtiocarboline (1), was isolated from a Papua New Guinea marine sponge, Hyrtios reticulatus. The structure was elucidated from spectroscopic data, including (1)H-(15)N HMBC NMR experiments, which provided complementary (15)N chemical shift information in support of the structure. This compound showed selective antiproliferative activity against H522-T1 non-small cell lung, MDA-MB-435 melanoma, and U937 lymphoma cancer cell lines.
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