A New Prenylated Flavonol from the Root of Petalostemon purpureus
Journal of Natural Products1996Vol. 59(3), pp. 290–292
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Li Huang, Fekadu Fullas, Robert McGivney, D. M. Brown, Mansukh C. Wani, Monroe E. Wall, John C. Tucker, Chris Beecher, John M. Pezzuto, A. Douglas Kinghorn
Abstract
A new prenylated flavonol, petalopurpurenol (1), and a known dihydroflavonol, petalostemumol (2), have been isolated by DNA scission-guided fractionation of the organic portion of a 20% MeOH/CHCl3/H2O partition of a 50% MeOH/CHCl3 extract of the roots of Petalostemon purpureus. Compound 2 displayed moderate activity in DNA-scission assay. Both compounds 1 and 2 were evaluated for cytotoxicity in a panel of human cancer cell lines. The structures of petalopurpurenol (1) and petalostemumol (2) were determined by spectroscopic analysis.
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