Nigranoic Acid, a Triterpenoid from Schisandra sphaerandra That Inhibits HIV-1 Reverse Transcriptase
Journal of Natural Products1996Vol. 59(5), pp. 525–527
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Han‐Dong Sun, Sheng‐Xiang Qiu, Long-Ze Lin, Zongyu Wang, Zhong‐Wen Lin, Thitima Pengsuparp, John M. Pezzuto, Harry H. S. Fong, Geoffrey A. Cordell, Norman R. Farnsworth
Abstract
An A ring-secocycloartene triterpenoid, nigranoic acid (3,4-secocycloarta-4(28),24-(Z)-diene-3,-26-dioic acid, (1) was isolated from the stems of Schisandra sphaerandra, a Chinese traditional medicinal plant. Its structure elucidation and unambiguous NMR spectral assignment were achieved by the combination of 1D- and 2D-NMR techniques with the aid of computer modeling. Nigranoic acid showed activity in several anti-HIV reverse transcriptase and polymerase assays.
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