Bioactive ent-Kaurene Diterpenoids from Annona senegalensis
Journal of Natural Products1996Vol. 59(3), pp. 301–303
Citations Over TimeTop 19% of 1996 papers
Majekodunmi O. Fatope, Oladimeji Audu, Yoshio Takeda, Lu Zeng, Guoen Shi, Hiroko Shimada, Jerry L. McLaughlin
Abstract
Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 microgram/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 micrograms/mL). The structure of the new compound, 3, was deduced from spectral evidence.
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