Two New Naphthoquinones with Antiviral Activity from Rhinacanthus nasutus
Journal of Natural Products1996Vol. 59(8), pp. 808–811
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A. Sendl, Jian Lu Chen, S.D. Jolad, Cheryl A. Stoddart, Edward J. Rozhon, Michael R. Kernan, Weerachai Nanakorn, Michael J. Balick
Abstract
Two new naphthoquinones, rhinacanthin-C (1) and rhinacanthin-D (2), exhibit inhibitory activity against cytomegalovirus (CMV), with EC50 values of 0.02 and 0.22 microgram/mL, respectively, against human CMV. They were isolated from the medicinal plant Rhinacanthus nasutus (Acanthaceae). The structures of the compounds were determined by analysis of their spectroscopic data, in particular, 2D NMR.
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