Dragmacidins: New Protein Phosphatase Inhibitors from a Southern Australian Deep-Water Marine Sponge, Spongosorites sp.
Journal of Natural Products1998Vol. 61(5), pp. 660–662
Citations Over TimeTop 10% of 1998 papers
Robert J. Capon, Francis Rooney, Leanne M. Murray, Elizabeth Collins, Alistair T.R. Sim, John A.P. Rostas, Mark S. Butler, Anthony R. Carroll
Abstract
A Spongosorites sp. collected during trawling operations off the southern coast of Australia returned the new alkaloid dragmacidin E (3), the structure of which was secured by detailed spectroscopic analysis. Dragmacidin E (3), and its co-metabolite dragmacidin D (1) have been identified as potent inhibitors of serine-threonine protein phosphatases.
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