Sideroxylonal C, a New Inhibitor of Human Plasminogen Activator Inhibitor Type-1, from the Flowers of Eucalyptus albens
Journal of Natural Products1999Vol. 62(2), pp. 324–326
Citations Over TimeTop 21% of 1999 papers
Juliette E. Neve, Priscila de Almeida Leone, Anthony R. Carroll, Roger W. Moni, Natalii J. Paczkowski, Greg Pierens, Petter Björquist, Johanna Deinum, J. Ehnebom, Tord Inghardt, Gordon P. Guymer, Paul Grimshaw, Ronald J. Quinn
Abstract
Sideroxylonal C (3), a new phloroglucinol dimer, was isolated from the flowers of Eucalyptus albens through bioassay-guided fractionation. The structure elucidation was based on 1D and 2D NMR experiments, MS analysis, and comparison with sideroxylonals A (1) and B (2). Sideroxylonal C inhibited human plasminogen activator inhibitor type-1 at 4.7 microM without any significant effect on human tissue plasminogen activator.
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