Symplostatin 1: A Dolastatin 10 Analogue from the Marine Cyanobacterium Symploca hydnoides
Journal of Natural Products1998Vol. 61(9), pp. 1075–1077
Citations Over TimeTop 11% of 1998 papers
George G. Harrigan, Hendrik Luesch, Wesley Y. Yoshida, Robert J. Moore, Dale G. Nagle, Valerie J. Paul, Susan L. Mooberry, Thomas H. Corbett, Fred A. Valeriote
Abstract
A new solid tumor selective cytotoxic analogue of dolastatin 10 (1) has been isolated from the marine cyanobacterium Symploca hydnoides, collected near Guam. This metabolite has been assigned the trivial name symplostatin 1 (2). This discovery supports the proposal that many compounds isolated from the seahare Dolabella auricularia, the original source of the dolastatins, are of dietary origin.
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