Synthetic Analogues of Irlbacholine: A Novel Antifungal Plant Metabolite Isolated from Irlbachia Alata
Journal of Natural Products1999Vol. 62(6), pp. 824–828
Citations Over Time
Qing Lü, Rosa Ubillas, Yihong Zhou, L. G. DUBENKO, Jeffrey M. Dener, Joane Litvak, Puay‐Wah Phuan, Martha Flores, Zhijun Ye, R. Eric Gerber, Thien Van Truong, Donald Bierer
Abstract
Irlbacholine and a series of related analogues were synthesized and their antifungal activities against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus were assessed. The natural bisphosphocholine, irlbacholine, was the most potent compound, its 22-carbon chain length appearing to be optimal.
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