General Approach for the Synthesis of Sarpagine/Ajmaline Indole Alkaloids. Stereospecific Total Synthesis of the Sarpagine Alkaloid (+)-Vellosimine

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Abstract

[reaction: see text] (+)-Vellosimine has been synthesized enantiospecifically in 27% overall yield from commercially available D-(+)-tryptophan methyl ester via the asymmetric Pictet-Spengler reaction and a stereocontrolled intramolecular palladium-coupling reaction as key steps.

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