A Novel and Highly Efficient Synthesis of gem-Difluorocyclopropanes
Organic Letters2000Vol. 2(4), pp. 563–564
Citations Over TimeTop 12% of 2000 papers
Feng Tian, Virginie Kruger, Olivia Bautista, Jianxin Duan, An‐Rong Li, William R. Dolbier, Qing‐Yun Chen
Abstract
[reaction: see text] A new and highly versatile source of difluorocarbene is reported. Trimethylsilyl fluorosulfonyldifluoroacetate (TFDA) undergoes decomposition in the presence of catalytic fluoride to form difluorocarbene under conditions that allow its addition to relatively electron deficient alkenes in high yield. For example, unprecedented CF2: addition to n-butyl acrylate proceeded in 73% yield.
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