Protein-Degrading Enediynes: Library Screening of Bergman Cycloaromatization Products
Organic Letters2000Vol. 2(13), pp. 1863–1866
Citations Over TimeTop 15% of 2000 papers
Abstract
[structure: see text] A screening method based on Bergman cycloaromatization products was applied to a compact library of estrogenic-enediyne hybrids. An enediyne candidate identified from the screen was subsequently synthesized, and it induced temperature- and concentration-dependent degradation of human estrogen receptor alpha upon cycloaromatization.
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