Enantiospecific and Regioselective Rhodium-Catalyzed Allylic Alkylation: Diastereoselective Approach to Quaternary Carbon Stereogenic Centers
Organic Letters2000Vol. 2(15), pp. 2213–2215
Citations Over TimeTop 10% of 2000 papers
Abstract
The enantiospecific and regioselective rhodium-catalyzed allylic alkylation of a series of chiral nonracemic allylic carbonates, followed by ozonolysis and reductive lactonization, provides a convenient route to optically active gamma-lactones. Sequential alkylation and reductive alkylation furnished the alpha-quaternary-beta-ternary substituted gamma-lactone derivative as a >/=10:1 mixture of diastereoisomers.
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