Staudinger Ligation: A Peptide from a Thioester and Azide
Organic Letters2000Vol. 2(13), pp. 1939–1941
Citations Over TimeTop 10% of 2000 papers
Abstract
[reaction: see text] The technique of native chemical ligation enables the total chemical synthesis of proteins. This method is limited, however, by an absolute requirement for a cysteine residue at the ligation juncture. Here, this restriction is overcome with a new chemical ligation method in which a phosphinobenzenethiol is used to link a thioester and azide. The product is an amide with no residual atoms.
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