Asymmetric Synthesis of the Northern Half C1−C16 of the Bryostatins
Organic Letters2001Vol. 3(6), pp. 929–932
Citations Over TimeTop 10% of 2001 papers
Abstract
Starting from 8-oxabicyclo[3.2.1]oct-6-en-3-one and racemic 2,2-dimethyl-8-oxabicyclo[3.2.1]oct-6-en-3-one, the C1-C16 segment of the bryostatins has been synthesized in 30 steps and 9% overall yield (17 steps longest linear sequence). Fragment coupling by dithiane strategy and protecting group manipulations provided an advanced chemodifferentiated northern half segment.
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