Synthesis of a Selenocysteine-Containing Peptide by Native Chemical Ligation
Organic Letters2001Vol. 3(9), pp. 1331–1334
Citations Over TimeTop 10% of 2001 papers
Abstract
[reaction in text] A new method for the synthesis of selenocysteine derivatives and selenocysteine-containing peptides is described. Fmoc-Se-p-methoxybenzylselenocysteine (1) was prepared and used for solid-phase synthesis of peptides with an N-terminal unprotected selenocysteine. Subsequent native chemical ligation with a peptide thioester provided a 17-mer that corresponds to the C-terminus of ribonucleotide reductase with selenocysteine in place of cysteine.
Related Papers
- → Azole reagents enabled ligation of peptide acyl pyrazoles for chemical protein synthesis(2024)13 cited
- → Sequential Peptide Ligation by Combining the Cys–Pro Ester (CPE) and Thioester Methods and Its Application to the Synthesis of Histone H3 Containing a Trimethyl Lysine Residue(2013)29 cited
- → Synthesis of Cyclic Peptides Containing a Thioester Handle for Native Chemical Ligation(2012)16 cited
- → Sequential peptide chemical ligation by the thioester method and extended chemical ligation(2005)10 cited
- → Native chemical ligation derived method for recombinant peptide/protein C-terminal amidation(2013)4 cited