Tandem Conjugate Reduction−Aldol Cyclization Using Stryker's Reagent
Organic Letters2001Vol. 3(12), pp. 1901–1903
Citations Over TimeTop 13% of 2001 papers
Abstract
[see reaction]. Conjugate reduction by Stryker's reagent to form copper enolates, followed by intramolecular aldol cyclization, successfully generated five- and six-membered carbocycles in one pot efficiently. This tandem reaction is generally diastereoselective and provides good yields of the beta-hydroxyketones without any dehydration at low temperatures.
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