An Efficient Synthesis of Morpholin-2-one Derivatives Using Glycolaldehyde Dimer by the Ugi Multicomponent Reaction
Organic Letters2001Vol. 3(26), pp. 4149–4152
Citations Over TimeTop 15% of 2001 papers
Young Bae Kim, Eun Hee Choi, Gyochang Keum, Soon Bang Kang, Duck‐Hyung Lee, Hun Young Koh, Youseung Kim
Abstract
A new one-pot procedure for the efficient synthesis of novel 3-substituted morpholin-2-one-5-carboxamide derivatives using commercially available glycolaldehyde dimer as a bifunctional component with various alpha-amino acids and isocyanides by the Ugi five-center three-component reaction (U-5C-3CR) was developed. [reaction: see text]
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