Akanthomycin, a New Antibiotic Pyridone from the Entomopathogenic Fungus Akanthomyces gracilis
Organic Letters2002Vol. 4(5), pp. 671–673
Citations Over TimeTop 19% of 2002 papers
Abstract
[structure: see text] Organic extracts of the entomopathogenic fungus Akanthomyces gracilis ARS 2910 contained antibiotics active against Staphylococcus aureus. Bioassay-guided fractionation of the CH2Cl2 extract yielded the antibacterial compound akanthomycin as a mixture of atropisomers along with the closely related compounds 8-methylpyridoxatin and cordypyridone C. Akanthomycin was characterized using X-ray crystallography and NMR.
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