Construction of Substituted Cyclohexanones by Reductive Cyclization of 7-Oxo-2,8-alkadienyl Esters
Organic Letters2001Vol. 4(1), pp. 79–82
Citations Over TimeTop 18% of 2001 papers
Abstract
[reaction: see text] Cyclization of 7-oxo-2,8-alkadienyl esters upon reaction with triphenylphosphinecopper hydride hexamer stereoselectively yields substituted cyclohexanones having a cis relationship of carbon side chains at C2 and C3. This cyclohexanone construction is particularly useful for preparing 4-alkoxy- or 4-siloxy-2,3-disubstituted cyclohexanones, in which instance stereoselection is > or = 20:1.
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