Efficient Enantioselective Additions of Terminal Alkynes and Aldehydes under Operationally Convenient Conditions
Organic Letters2002Vol. 4(15), pp. 2605–2606
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Abstract
[reaction: see text] The enantioselective addition reaction of terminal acetylenes and aldehydes mediated by Zn(OTf)2 and N-methyl ephedrine can be conducted with reagent grade solvent containing 84-1000 ppm H2O. The products can be isolated in high yield and useful enantioselectivities (up to 99% ee).
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