Intramolecular Cyclization of Acyl Radicals onto the Azido Group: A New Radical Approach to Cyclized Lactams
Organic Letters2002Vol. 4(18), pp. 3079–3081
Citations Over TimeTop 10% of 2002 papers
Luisa Benati, Rino Leardini, Matteo Minozzi, Daniele Nanni, Piero Spagnolo, Samantha Strazzari, Giuseppe Zanardi
Abstract
[reaction: see text] Aryl- and alkyl-derived azidoacyl radicals, generated from thiolesters by intramolecular homolytic substitution at the sulfur, can undergo five- and six-membered cyclization onto the azido moiety to give cyclized lactams.
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