Synthesis and 12-Helical Secondary Structure of β-Peptides Containing (2R,3R)-Aminoproline
Organic Letters2002Vol. 4(19), pp. 3317–3319
Citations Over TimeTop 14% of 2002 papers
Abstract
[structure: see text] (2R,3R)-Aminoproline, a pyrrolidine-based beta-amino acid, was synthesized and incorporated into hexa-beta-peptide 4. This residue confers water solubility when the ring nitrogen is protonated and allows for 12-helix formation in aqueous solution. Circular dichroism spectra display the 12-helical signature, and 12-helical structure was confirmed by 2D NMR analysis.
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