Copper(I) Hydride-Catalyzed Asymmetric Hydrosilylation of Heteroaromatic Ketones
Organic Letters2002Vol. 4(23), pp. 4045–4048
Citations Over TimeTop 10% of 2002 papers
Abstract
In situ generation of CuH ligated by Takasago's new nonracemic ligand, DTBM-SEGPHOS, leads to an especially reactive reagent capable of effecting asymmetric hydrosilylation of heteroaromatic (H) ketones under very mild conditions. PMHS serves as an inexpensive source of hydride. Substrate-to-ligand ratios on the order of 2000:1 are employed. [reaction: see text]