UCS1025A and B, New Antitumor Antibiotics from the Fungus Acremonium Species
Organic Letters2002Vol. 4(25), pp. 4387–4390
Citations Over TimeTop 19% of 2002 papers
Tsutomu Agatsuma, Tsutomu Akama, Shinji Nara, S. Matsumiya, Ryuichiro Nakai, Harumi Ogawa, Shizuo Otaki, Shun‐ichi Ikeda, Yutaka Saitoh, Yutaka Kanda
Abstract
[structure: see text] UCS1025A and B, novel pentacyclic polyketides with an unprecedented furopyrrolizidine skeleton, were isolated from the fungus Acremonium sp. KY4917. The structures and stereochemistry were elucidated by a combination of two-dimensional NMR and X-ray crystallographic analysis. UCS1025A showed unique chemical equilibria involving three tautomeric isomers and exhibited antimicrobial activity and antiproliferative activity against human tumor cell lines.
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