Parallel Synthesis of Glycomimetic Libraries: Targeting a C-Type Lectin
Organic Letters2003Vol. 5(9), pp. 1407–1410
Citations Over TimeTop 15% of 2003 papers
Michael C. Schuster, David A. Mann, Tonia J. Buchholz, Kathryn M. Johnson, William D. Thomas, Laura L. Kiessling
Abstract
We have developed methods for the parallel synthesis of two libraries of non-carbohydrate-based analogues of mannose on a solid support. The natural product shikimic acid was used as a key building block. The ability of the compounds to block the binding of the C-type lectin MBP-A to a mannosylated surface was assessed in a high-throughput assay. Ten library members with inhibitory activities equivalent to that of alpha-methyl mannopyranoside were identified. [reaction: see text]
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