Novel Method for Incorporating the CHF2 Group into Organic Molecules Using BrF3
Organic Letters2003Vol. 5(5), pp. 769–771
Citations Over TimeTop 10% of 2003 papers
Abstract
2-Alkyl-1,3-dithiane derivatives, easily made from alkyl bromides and the parent 1,3-dithiane, were reacted with BrF(3) to form the corresponding 1,1-difluoromethyl alkanes (RCHF(2)) in 60-75% yield. The reaction proceeds well with primary alkyl halides. The limiting step for secondary alkyl halides is the relatively low yield of the dithiane preparation. The two sulfur atoms of the dithiane are essential for the reaction.
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