A Synthetic Approach to Nomofungin/Communesin B
Organic Letters2003Vol. 5(18), pp. 3169–3171
Citations Over TimeTop 14% of 2003 papers
Abstract
[reaction: see text] A highly stereoselective intramolecular cycloaddition of an indole tethered to an aza-ortho-xylylene intermediate effects the rapid construction of a substantial portion of the ring system of the cytotoxic natural product communesin B. An analogous cycloaddition involving an ortho-quinone methide intermediate provides an adduct that clearly revealed that the structural assignment for nomofungin was in error.
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