Highly Stereoselective Anti SN2‘ Substitutions of (Z)-Allylic Pentafluorobenzoates with Polyfunctionalized Zinc−Copper Reagents
Organic Letters2003Vol. 5(12), pp. 2111–2114
Citations Over TimeTop 10% of 2003 papers
Abstract
[reaction: see text] Allylic substitution reactions of zinc-copper organometallics on (Z)-allylic pentafluorobenzoates proceed with very high regioselectivity and excellent anti selectivity. The high fidelity in transfer of stereochemical information allowed a short synthesis of (+)-ibuprofen (97% ee).
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