Regioselective Formation, Using Orthogonal Cysteine Protection, of an α-Conotoxin Dimer Peptide Containing Four Disulfide Bonds
Organic Letters2003Vol. 5(16), pp. 2955–2957
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Abstract
[structure: see text] The combination of the cysteine thiol protecting groups Trt, Acm, tBu, and MeBzl were used for the regioselective formation of an alpha-conotoxin dimer peptide containing four disulfide bridges. Additionally, a protocol is described whereby two one-pot oxidations were employed in order to improve the efficiency of the folding process. The target compound was produced in good yield.
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