Efficient Asymmetric Synthesis of the Vasopeptidase Inhibitor BMS-189921
Organic Letters2003Vol. 5(17), pp. 3155–3158
Citations Over TimeTop 15% of 2003 papers
Janak Singh, David R. Kronenthal, Mark D. Schwinden, Jollie D. Godfrey, R. W. Fox, Edward J. Vawter, Bo Zhang, Thomas P. Kissick, Bharat Patel, Omar Mneimne, Michael Humora, Chris G. Papaioannou, Walter Szymanski, Michael K. Y. Wong, Chien K. Chen, James E. Heikes, John D. DiMarco, Jun Qiu, Rajendra P. Deshpande, Jack Z. Gougoutas, Richard H. Mueller
Abstract
[reaction: see text] An efficient asymmetric synthesis of the vasopeptidase inhibitor BMS-189921 was accomplished. Two short enantioselective syntheses of the common key intermediate (S)-alpha-aminoazepinone 6b were developed. Olefin 3 was converted to 6b via asymmetric hydrogenation. Alternatively, enyne 12 was converted to racemic alpha-aminoazepinone 15b, which was transformed to 6b by a practical dynamic resolution.
Related Papers
- A GEOMETRIC MEAN IN THE FURUTA INEQUALITY(2002)
- Susquehanna Chorale Spring Concert "Roots and Wings"(2017)
- Коммуникaтивно- прaгмaтический aнaлиз дипломaтических бумaг (нa основе вербaльных нот)(2018)
- → ФОРМИРОВAНИЕ ГОТОВНОСТИ БУДУЩИХ ПЕДAГОГОВ К ОРГAНИЗAЦИИ РAБОТЫ ПО РAЗВИТИЮ ВAЛЕОЛОГИЧЕСКОЙ КУЛЬТУРЫ ШКОЛЬНИКОВ(2023)