Catalytic, Three-Component Assembly Reaction for the Synthesis of Pyrrolidines
Organic Letters2003Vol. 5(19), pp. 3487–3490
Citations Over TimeTop 10% of 2003 papers
Abstract
[reaction: see text] Copper(I) salts catalyze the three-component assembly reaction between an alpha-diazo ester, an imine, and various alkenes and alkynes to form substituted pyrrolidines with excellent to good diastereoselectivities in high yields. The transition metal-catalyzed decomposition of the alpha-diazo compound in the presence of the imine likely generates a transient azomethine ylid that undergoes addition with various dipolarophiles in a highly convergent manner.
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