First Examples of Transition-Metal Free Sonogashira-Type Couplings
Organic Letters2003Vol. 5(21), pp. 3919–3922
Citations Over TimeTop 10% of 2003 papers
Abstract
[reaction: see text] We report here our observation that, using appropriate reaction conditions, the Sonogashira reaction can be performed without the need for transition-metal catalysts. Our approach involves the use of water as a solvent, poly(ethylene glycol) as a phase-transfer agent, and sodium hydroxide as a base. The methodology works, to differing extents, for aryl iodides and bromides.
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