First Total Synthesis and Stereochemical Definition of Isodomoic Acid G
Organic Letters2003Vol. 5(20), pp. 3771–3773
Citations Over TimeTop 10% of 2003 papers
Abstract
[structure: see text] The first total synthesis and stereochemical definition of isodomoic acid G has been achieved. The key nickel-catalyzed coupling of an alkynyl enone with an alkenylzirconium allows formation of the pyrrolidine ring and most of the stereochemical features in a single step. This report provides the first total synthesis application of this new reaction and illustrates its utility in the stereoselective preparation of highly substituted 1,3-dienes.
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