Efficient and General Protocol for the Copper-Free Sonogashira Coupling of Aryl Bromides at Room Temperature
Organic Letters2003Vol. 5(22), pp. 4191–4194
Citations Over TimeTop 1% of 2003 papers
Abstract
[reaction: see text]. A mild and general protocol for the copper-free Sonogashira coupling of aryl bromides with acetylenes has been developed. The use of (AllylPdCl)2 and P(t-Bu)3 provides the active Pd(0) catalyst that allows subsequent coupling of various alkynes at room temperature with good to excellent yields.
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