Toward a Total Synthesis of Peloruside A: Enantioselective Preparation of the C8−C19 Region
Organic Letters2003Vol. 5(26), pp. 4959–4961
Citations Over TimeTop 20% of 2003 papers
Abstract
An efficient synthetic sequence toward the C8-C19 region of peloruside A has been developed. The route is highlighted by a selective electrophilic cyclization reaction, a single-step epoxide ring-opening/methylation sequence, and a stereoselective Mukaiyama aldol reaction. [reaction: see text]
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