Synthesis of Secondary Arylamines through Copper-Mediated Intermolecular Aryl Amination
Organic Letters2003Vol. 5(26), pp. 4987–4990
Citations Over TimeTop 10% of 2003 papers
Abstract
A mild intermolecular copper-mediated amination of aryl iodides has been developed. The reaction takes place at room temperature or heating at 90 degrees C and tolerates halogens attached to the aromatic ring. Its synthetic applications include a synthetic protocol for unsymmetrical N,N'-dialkylated phenylenediamines and both a stepwise and a general synthetic method for N-aryl secondary amines via Ns-anilides (readily obtained by reaction of the Ns-amide). [reaction: see text]
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