Novel Dolabellane-Type Diterpene Alkaloids with Lipid Metabolism Promoting Activities from the Seeds of Nigella sativa
Organic Letters2004Vol. 6(6), pp. 869–872
Citations Over TimeTop 10% of 2004 papers
Toshio Morikawa, Fengming Xu, Yousuke Kashima, Hisashi Matsuda, Kiyofumi Ninomiya, Masayuki Yoshikawa
Abstract
[structure: see text] Four new dolabellane-type diterpene alkaloids, nigellamines A(1) (1), A(2) (2), B(1) (3), and B(2) (4), were isolated from the seeds of Nigella sativa. Their absolute stereostructures were determined on the basis of chemical and physicochemical evidence. Nigellamines A(1) (1), B(1) (3), and B(2) (4) were found to show potent lipid metabolism promoting activity in primary cultured mouse hepatocytes, and their activities were equivalent to that of a PPAR-alpha agonist, clofibrate.
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