Synthesis of Pelorol and Analogues: Activators of the Inositol 5-Phosphatase SHIP
Organic Letters2005Vol. 7(6), pp. 1073–1076
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Lu Yang, David E. Williams, Alice Mui, Christopher J. Ong, Gerald Krystal, Rob W. M. van Soest, Raymond J. Andersen
Abstract
[reaction: see text] A screening program designed to find new antiinflammatory agents has identified the sponge meroterpenoid pelorol (1) as an in vitro activator of the inositol-5-phosphatase SHIP. Pelorol (1) and several functional group analogues have been synthesized from sclareolide (4).
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