Rapid Microwave-Assisted Solid-Phase Glycopeptide Synthesis
Organic Letters2005Vol. 7(5), pp. 877–880
Citations Over TimeTop 10% of 2005 papers
Abstract
Coupling of glycosylated Fmoc-Thr or Fmoc-Ser with N-terminal amino acids on a resin proceeded smoothly under microwave irradiation for 20 min with much higher efficiency (98% yield per coupling) than found in more general conditions. Compared with a conventional protocol, the present method greatly reduces the time required for solid-phase glycopeptide synthesis from 4 days to 7 h, as is the case with the synthesis of Muc-1-related 20-residue glycopeptide carrying five core-2 trisaccharide chains. [structure: see text]
Related Papers
- → Preparation of a glycopeptide analogue of type II collagen — Use of acid labile protective groups for carbohydrate moieties in solid phase synthesis of O-linked glycopeptides(1996)27 cited
- → Glycopeptides and glycoproteins : synthesis, structure, and application(2007)15 cited
- → Observations on the reaction of 2-hydroxy-5-nitrobenzyl bromide with a peptide-bound tryptophanyl residue(1984)8 cited
- → Preparation and Screening of Glycopeptide Libraries(2001)2 cited
- → The comparison of an acidic glycopeptide from the ascitic tumor fluid and of the glycopeptide from Ehrlich cells(1982)