Asymmetric Synthesis of 3-Substituted Isoindolinones: Application to the Total Synthesis of (+)-Lennoxamine
Organic Letters2004Vol. 7(1), pp. 95–98
Citations Over TimeTop 10% of 2004 papers
Abstract
An anionic chiral auxiliary mediated asymmetric alkylation of carbamate 2 provides 3-substituted isoindolinones 4 in high ee. This methodology was used in the first asymmetric synthesis of (+)-lennoxamine.
Related Papers
- → Enantioselective Total Syntheses of the Cyclotryptamine Alkaloids Hodgkinsine and Hodgkinsine B(2003)74 cited
- → Enantioselective Total Synthesis of (+)‐Vittatalactone(2011)29 cited
- → A short and efficient enantioselective route to a key intermediate for the total synthesis of forskolin(1989)63 cited
- → Enantioselective formal total synthesis of (−)-trachyspic acid(2009)14 cited
- → Enantioselective Synthesis of β-Lactams Using a Chiral Auxiliary(2006)1 cited