The First Regioselective Palladium-Catalyzed Indolization of 2-Bromo- or 2-Chloroanilines with Internal Alkynes: A New Approach to 2,3-Disubstituted Indoles
Organic Letters2004Vol. 6(22), pp. 4129–4132
Citations Over TimeTop 10% of 2004 papers
Ming Shen, Guisheng Li, Bruce Z. Lu, Azad Hossain, Frank Roschangar, Vittorio Farina, Chris H. Senanayake
Abstract
[reaction: see text] The first practical and economical process for synthesis of 2,3-disubstituted indole compounds has been developed with high regioselectivity by palladium-catalyzed indolization of 2-bromo- or chloroanilines and their derivatives with internal alkynes.
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