A Concise Asymmetric Synthesis of the ADE Fragment of Nakadomarin A
Organic Letters2004Vol. 6(24), pp. 4539–4541
Citations Over TimeTop 10% of 2004 papers
Abstract
The ADE fragment of nakadomarin A has been synthesized in nine linear steps from commercial material. The key transformation is an asymmetric azomethine ylide [1,3]-dipolar cycloaddition to establish the AD-spirocyclic system containing three of the four stereocenters of the natural product. [reaction: see text]
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