Maoecrystal V, Cytotoxic Diterpenoid with a Novel C19 Skeleton from Isodon eriocalyx (Dunn.) Hara
Organic Letters2004Vol. 6(23), pp. 4327–4330
Citations Over Time
Sheng-Hong Li, Jia Wang, Xue‐Mei Niu, Yun‐Heng Shen, Hongjie Zhang, Han-Dong Sun, Malin Li, Qin-E Tian, Yang Lü, Peng Cao, Qi-Tai Zheng
Abstract
Maoecrystal V (1), a novel C(19) diterpenoid possessing a unique 6,7-seco-6-nor-15(8-->9)-abeo-5,8-epoxy-ent-kaurane skeleton, was isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx. Its structure was determined by comprehensive NMR and MS spectroscopic analysis and confirmed by single-crystal X-ray diffraction study. Compound 1 showed remarkable inhibitory activity toward HeLa cells with IC(50) = 0.02 microg/mL (cis-platin: IC(50) = 0.99 microg/mL).
Related Papers
- → Clerodane Diterpenoid Glucosides from the Stems of Tinospora sinensis(2017)53 cited
- → Chemical constituents from Euphorbia stracheyi and their biological activities(2014)35 cited
- → Isolation, synthesis, and anti-tumor activities of a novel class of podocarpic diterpenes(2005)39 cited
- → Cytotoxic diterpenoid quinonemethides from the roots of Pygmacopremna herbacea(2011)14 cited
- → Cytotoxic components from the Xisha sponge Fascaplysinopsis reticulata(2018)9 cited