A Highly Diastereoselective MgI2-Mediated Ring Expansion of Methylenecyclopropanes
Organic Letters2004Vol. 6(19), pp. 3309–3312
Citations Over TimeTop 10% of 2004 papers
Abstract
[reaction: see text] A highly diastereoselective MgI(2)-mediated ring expansion of methylenecyclopropane amides to functionalized pyrrolidines has been developed using chiral aromatic sulfinimines. The 2,3,4-trisubstituted pyrrolidines were isolated in generally good to excellent yields and in excellent diastereoselectivities for aromatic and heterocyclic sulfinimines.
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