Role of Noncovalent Interactions in the Enantioselective Reduction of Aromatic Ketimines with Trichlorosilane
Organic Letters2004Vol. 6(13), pp. 2253–2256
Citations Over TimeTop 10% of 2004 papers
Abstract
[reaction: see text] Asymmetric reduction of ketimines 1 with trichlorosilane can be catalyzed by a new N-methyl L-valine derived Lewis basic organocatalyst, such as 4d, with high enantioselectivity. The structure-reactivity investigation suggests hydrogen bonding and arene-arene interactions between the catalyst and the incoming imine as the main factor determining the enantiofacial selectivity.
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