Discovery of the Chemical Function of Glycosidases: Design, Synthesis, and Evaluation of Mass-Differentiated Carbohydrate Libraries
Organic Letters2004Vol. 6(12), pp. 2031–2033
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Abstract
[reaction: see text] Discovery of the catalytic chemical function of the many putative glycosidases coded in genomes currently relies on individual testing of possible substrates, usually as their p-nitrophenol conjugate. Herein, we present an alternative chemical proteomics approach using a synthetic mass-differentiated heat-stable substrate library with mass spectrometry readout. Library components do not serve as reaction inhibitors and both primary and secondary enzyme substrates can be delineated.
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